Method for modifying the wettability and other biocompatibility characteristics of a surface of a biological material by the application of beam technology and biological materials made thereby

摘要

A method of preparing a preformed bone shape for implantation provides irradiating at least a portion of a preformed bone shape by a Neutral Beam derived from a GCIB, and the preformed bone shape so irradiated.

主权项

1. A method for preparing a preformed bone shape for surgical implantation, said method comprising:
providing a reduced pressure chamber; forming a first accelerated Neutral Beam derived from a gas-cluster ion beam, within said reduced pressure chamber; providing a holder within said reduced pressure chamber for holding the preformed bone shape; positioning a preformed bone shape in the holder in said reduced pressure chamber; and first irradiating at least a portion of a first surface of the preformed bone shape with the Neutral Beam to form a first barrier layer on the portion, wherein the first barrier layer is effective to modify the elution rate of one or more bone growth factors naturally present in the preformed bone shape.