| 主权项 |
1. A compound of the Formula (E): or a salt thereof, wherein:
R1 is H, hydroxyl, nitro, cyano, halo, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C2-C8 alkynyl, perhaloalkyl, acyl, acyloxy, carbonylalkoxy, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, C1-C8 perhaloalkoxy, alkoxy, aryloxy, carboxyl, thiol, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl or carbonylalkylenealkoxy;each R2a and R2b is independently H, substituted or unsubstituted C1-C8 alkyl, halo, cyano, hydroxyl, alkoxy, nitro or R2a and R2b are taken together with the carbon to which they are attached to form a cycloalkyl moiety or a carbonyl moiety;each R3a and R3b is independently H, substituted or unsubstituted C1-C8 alkyl, halo, cyano hydroxyl, alkoxy, nitro or R3a and R3b are taken together with the carbon to which they are attached to form a cycloalkyl moiety or a carbonyl moiety;each X7, X8, X9 and X10 is independently CR4;m and q are independently 0 or 1;n is 1;each R4 is independently H, hydroxyl, nitro, cyano, halo, C1-C8 perhaloalkyl, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C2-C8 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, C1-C8 perhaloalkoxy, C1-C8 alkoxy, aryloxy, carboxyl, thiol, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aralkyl, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl, carbonylalkylenealkoxy, alkylsulfonylamino or acyl;each R8a, R8b, R8c, R8d, R8e and R8f is independently H, hydroxyl, substituted or unsubstituted alkyl or is taken together with the carbon to which it is attached and a geminal R8(a-f) to form a cycloalkyl moiety;each R10a and R10b is independently H, substituted or unsubstituted C1-C8 alkyl, halo, hydroxyl, alkoxyl or R10a and R10b are taken together with the carbon to which they are attached to form a cycloalkyl moiety or a carbonyl moiety; andQ is acyclic or cyclic acylamino, acyloxy, aminoacyl, or aminocarbonylalkoxy;provided that: Q is cyclic acylamino only when each of m, n and q is 1, and (ii) the compound is other than a compound selected from the group consisting of compounds: 2H-Pyrido[4,3-b]indole-2-carboxylic acid, 5-[2-(dimethylamino)-2-oxoethyl]-1,3,4,5-tetrahydro-8-[(4-methyl-1-piperidinyl)carbonyl]-, 1,1-dimethylethyl ester (Compound No. 1x); 5H-Pyrido[4,3-b]indole-5-acetamide, 1,2,3,4-tetrahydro-N,N-dimethyl-8-[(4-methyl-1-piperidinyl)carbonyl]- (Compound No. 2x); 5H-Pyrido[4,3-b]indole-5-acetamide, 2-cyclobutyl-1,2,3,4-tetrahydro-N,N-dimethyl-8-[(4-methyl-1-piperidinyl)carbonyl]- (Compound No. 3x); 5H-Pyrido[4,3-b]indole-5-acetamide, 2-cyclohexyl-1,2,3,4-tetrahydro-N,N-dimethyl-8-[(4-methyl-1-piperidinyl)carbonyl] (Compound No. 4x); 5H-Pyrido[4,3-b]indole-5-acetamide, 2-cyclopentyl-1,2,3,4-tetrahydro-N,N-dimethyl-8-[(4-methyl-1-piperidinyl)carbonyl]- (Compound No. 5x); 5H-Pyrido[4,3-b]indole-5-acetamide, 8-formyl-1,2,3,4-tetrahydro-2-(1-methylethyl)- (Compound No. 6x); 5H-Pyrido[4,3-b]indole-5-acetamide, 1,2,3,4-tetrahydro-2-(1-methylethyl)- (Compound No. 11x); 5H-Pyrido[4,3-b]indole-5-acetamide, 1,2,3,4-tetrahydro-2,8-bis(1-methylethyl)- (Compound No. 12x); 5H-Pyrido[4,3-b]indole-5-acetamide, 1,2,3,4-tetrahydro-8-methyl-2-(1-methylethyl)- (Compound No. 13x); 5H-Pyrido[4,3-b]indole-5-acetamide, N-cyclohexyl-1,2,3,4-tetrahydro-2-(1-methylethyl)-(Compound No. 14x); 5H-Pyrido[4,3-b]indole-5-acetamide, N-cyclopentyl-1,2,3,4-tetrahydro-2-(1-methylethyl)- (Compound No. 15x); and 5H-Pyrido[4,3-b]indole-5-propanamide, 1,2,3,4-tetrahydro-2-methyl- (Compound No. 63x); and salts thereof. |
