1,3,5-triazine-2-amine derivatives, preparation thereof and diagnostic and therapeutic use thereof

摘要

The present invention relates to compounds corresponding to formula (I) in which: —R1 represents a substituted phenyl; —R2 represents: —a substituted phenyl; —a heteroaromatic group, the said group being unsubstituted or substituted one or more times; —R3 represents a group Alk; —R4 represents a hydrogen atom or a (C1-C4)alkyl; —R5 represents a hydrogen atom, a (C3-C6)cycloalkyl or a (C1-C4)alkyl-O-Alk; —or alternatively R4 and R5, together with the nitrogen atom to which they are attached, constitute a heterocyclic radical chosen from: azetidin-1-yl, pyrrolidin-1-yl, piperid-1-yl, morpholin-4-yl; —R6 represents a group —COOAlk, a group —CONH2 or a group —NHSO2Alk; —Alk represents a (C1-C4)alkyl, which is unsubstituted or substituted one or more times with a halogen atom; in the form of the base or of an acid-addition salt. Preparation process and diagnostic and therapeutic use.;

主权项

1. Compound corresponding to formula (I):wherein:
R1 is a phenyl substituted one or more substituents independently chosen from halogen, -Alk and —OAlk; R2 is:
phenyl substituted one or more substituents independently chosen from halogen, cyano, hydroxyl, nitro, -Alk, —OAlk, —SAlk, —SO2Alk, —COAlk, —SO2NR4R5, —(C1-C6)alkyl-OH, —(C1-C4)alkyl-COOAlk, —O—(C1-C4)alkyl-R6, methylenedioxy and an ethylenedioxy; orheteroaromatic unsubstituted or substituted one or more substituents independently chosen from halogen, cyano, -Alk, —OAlk, —SAlk or —N(Alk)2; R3 is Alk; R4 a is hydrogen or a (C1-C4)alkyl; R5 a is hydrogen, (C3-C6)cycloalkyl or (C1-C4)alkyl-O-Alk; or alternatively R4 and R5, together with the nitrogen atom to which they are attached, constitute a heterocyclic radical chosen from: azetidin-1-yl, pyrrolidin-1-yl, piperid-1-ylor morpholin-4-yl; R6 group is —COOAlk, —CONH2 or —NHSO2Alk;wherein Alk is (C1-C4)alkyl, unsubstituted or substituted one or more halogen;in the form of the base or of an acid-addition salt.