Partículas amorfas sólidas e processo para obter-las para uso em medicamento inalável

摘要

A method of making an inhalable medicament is provided, in particular a new solid-state form of tiotropium bromide. The medicament can be in the form of solid amorphous particles containing an intimate admixture of tiotropium bromide together with a pharmaceutically acceptable co-solid having a glass transition temperature of at least−50.degree. C., such as a sugar and/or sugar alcohol.