| 发明名称 | Gene expression and eradication system in <i>Helicobacter pylori</i> | ||
| 摘要 | The present invention relates to a gene expression and eradication system for Helicobacter pylori (H. pylori). In particular, the present invention relates to a genetic construct comprising, in the 5′-3′ direction: (a) a promoter sequence and (b) a DNA sequence of interest, wherein the promoter sequence comprises a polynucleotide sequence capable of regulating expression of the DNA sequence of interest in Helicobacter pylori and wherein said promoter sequence is modified to comprise a tetracycline (tet) operator sequence. | ||
| 申请公布号 | US9115363(B2) | 申请公布日期 | 2015.08.25 |
| 申请号 | US201214003786 | 申请日期 | 2012.03.09 |
| 申请人 | Ondek Pty Ltd | 发明人 | Benghezal Mohammed;Debowski Aleksandra Weronika;Sehnal Miriam;Dieye Yakhya;Park Se-Hoon;Marshall Barry |
| 分类号 | C12N15/74;A61K35/00 | 主分类号 | C12N15/74 |
| 代理机构 | Pepper Hamilton LLP | 代理人 | Pepper Hamilton LLP |
| 主权项 | 1. A genetic construct comprising, in the 5′-3′ direction: (a) a promoter sequence and (b) a urease operon, wherein the promoter sequence comprises a polynucleotide sequence capable of regulating expression of the urease operon in Helicobacter pylori and wherein said promoter sequence is modified to comprise a tetracycline (tet) operator sequence. | ||
| 地址 | New South Wales AU | ||