Transdermal therapeutic system reinforced by ultrasounds

摘要

The invention relates to a transdermal therapeutic system (10) comprising a pharmaceutical active agent formulation (13), an adhesive layer (11) comprising a contact surface (12), and at least one ultrasound transmitter (21), the side of the ultrasound transmitter opposing the contact surface being directly or indirectly adjacent to the pharmaceutical active agent formulation. The transdermal therapeutic system is a multi-layered laminate, one of the laminate layers comprising the ultrasound transmitter, another comprising the adhesive layer, and another comprising the pharmaceutical active agent formulation. Furthermore, from a top view, at least in a plane position of the transdermal therapeutic system, all of the laminate layers (11, 21, 14) are at least approximately mutually congruent and are at least approximately the size of the contact surface. The inventive system provides an ultrasound-reinforced transdermal therapeutic system characterized by an extensive use of active agents, enabling an improved absorption of active agents through the skin.

主权项

1. A transdermal therapeutic system comprising a multilayer laminate containing a pharmaceutical active substance formulation incorporated in an adhesive layer, the system including:
the adhesive layer having a first side comprising a skin contact surface for adhering to skin to be treated and a second side facing away from the skin contact surface; and an ultrasound transmitter layer located on the second side of the adhesive layer and comprising an ultrasound transmitter and microneedles mounted on and extending from the ultrasound transmitter into the adhesive layer and through the skin contact surface of the adhesive layer; wherein the ultrasound transmitter is directly adjacent to the adhesive layer having the pharmaceutical active substance formulation incorporated therein; and wherein, at least in a top view with the transdermal therapeutic system lying flat, the layers of the multilayer laminate are at least congruent to one another and have a size at least as great as a size of the skin contact surface.