发明名称 |
Alternative splicing variant of OATP1B3 mRNA |
摘要 |
An object of the present invention is to provide a novel tumor marker and use thereof. In more detail, the present invention provides a novel tumor marker, a method for measuring said tumor marker and a measurement kit, a method for detecting cancer using the same, a kit for detecting cancer, a method for screening a preventive and/or therapeutic agent for cancer, as well as a medicament such as cancer vaccine. According to the present invention, a method for measuring an alternative splicing variant of OATPIB3 mRNA in a sample to be examined is provided. Said measurement method comprises measuring mRNA comprising a nucleotide sequence represented by SEQ ID NO: 1 in the sequence listing table in a sample to be examined isolated from living organism with differentiation from a mRNA comprising a nucleotide sequence represented by SEQ ID NO: 2. Said measurement method is useful for detecting cancer or screening a preventive and/or therapeutic agent. |
申请公布号 |
US9115405(B2) |
申请公布日期 |
2015.08.25 |
申请号 |
US201313759101 |
申请日期 |
2013.02.05 |
申请人 |
National University Corporation Chiba University |
发明人 |
Furihata Tomomi;Matsumoto Sayaka;Nagai Miki;Chiba Kan |
分类号 |
C07H21/04;C12Q1/68;C07K14/47;G01N33/50;A61K39/00 |
主分类号 |
C07H21/04 |
代理机构 |
Cesari and McKenna, LLP |
代理人 |
Cesari and McKenna, LLP |
主权项 |
1. A method for measuring an alternative splicing variant of OATP1B3 (Organic Anion Transporting Polypeptide 1B3) mRNA in a sample isolated from a human, the method comprising amplifying by an RT-PCR assay an mRNA comprising SEQ ID NO: 1, wherein the RT-PCR assay does not amplify an mRNA comprising SEQ ID NO: 2. |
地址 |
Chiba-Shi JP |