| 主权项 |
1. A method of catalyzing an olefin metathesis reaction, comprising contacting a ruthenium complex of Formula I with an olefin compound;wherein:
L is a neutral ligand; R1 is C1-12 alkyl, C3-10 cycloalkyl, C6-14 aryl, heteroaryl, heterocyclyl, or —NR3bR3c; R2 is H, C1-12 alkyl, C3-10 cycloalkyl, or C6-14 aryl; R3 is halo, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, heteroaryl, heterocyclyl, —C(O)R3a, —C(O)OR3a, —C(O)NR3bR3c, —OR3a, —NR3bR3c, —NR3aC(O)R3b, —NR3aC(O)OR3b, —NR3aS(O)2R3b, —PR3aR3b, —P(OR3a)R3b, —P(OR3a)(OR3b), —P(O)R3aR3b, —P(O)(OR3a)R3b, —P(O)(OR3a)(OR3b), —S(O)2R3a, or —SO2NR3bR3c, R4 is C1-12 alkyl, C3-10 cycloalkyl, C7-15 aralkyl, or —C(R4aR4b)C(O)NR4cR4d; R5 is hydrogen, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-10 cycloalkyl, or C6-14 aryl; each R3a and R3d is independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, heteroaryl, or heterocyclyl; each R3b and R3c is independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, heteroaryl, or heterocyclyl; or R3b and R3c together with the N atom form a heteroaryl or heterocyclyl; R4a and R4b are each independently hydrogen, C1-6 alkyl, C3-8 cycloalkyl, C6-14 aryl, or C7-15 aralkyl; and R4c and R4d are each independently hydrogen, C1-6 alkyl, C3-8 cycloalkyl, C6-14 aryl, or C7-15 aralkyl; or R4c and R4d together with the N atom form heterocyclyl; X1 and X2 are each independently an anionic ligand; Y is a bond or —NRb—; Z is O or S; and n is an integer of 0, 1, 2, or 3; wherein each alkyl, alkenyl, alkynyl, aryl, aralkyl, cycloalkyl, heterocyclyl, and heteroaryl is optionally substituted with one or more groups, each independently selected from (a) cyano, halo, or nitro; (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl, each optionally substituted with one or more substituents Q; or (c) —C(O)Ra, —C(O)ORa, —C(O)NRbRc, —C(NRa)NRbRc, —ORa, —OC(O)Ra, —OC(O)ORa, —OC(O)NRbRc, —OC(═NRa)NRbRc, —OS(O)Ra, —OS(O)2Ra, —OS(O)NRbRc, —OS(O)2NRbRc, —NRbRc, —NRaC(O)Rd, —NRaC(O)ORd, —NRaC(O)NRbRc, —NRaC(═NRd)NRbRc, —NRaS(O)Rd, —NRaS(O)2Rd, —NRaS(O)NRbRc, —NRaS(O)2NRbRc, —PRaRd, —P(ORa)Rd, —P(ORa)(ORd), —P(O)RaRd, —P(O)(ORa)Rd, —P(O)(ORa)(ORd), —SRa, —S(O)Ra, —S(O)2Ra, or —SO2NRbRc; wherein each Ra, Rb, Rc, and Rd is independently hydrogen; C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl, each optionally substituted with one or more substituents Q; or Rb and Rc together with the N atom to which they are attached form heterocyclyl, optionally substituted with one or more substituents Q; wherein each Q is independently selected from the group consisting of (i) cyano, halo, or nitro; (ii) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; or (iii) —C(O)Re, —C(O)ORe, —C(O)NRfRg, —C(NRe)NRfRg, —ORe, —OC(O)Re, —OC(O)ORe, —OC(O)NRfRg, —OC(═NRe)NRfRg, —OS(O)Re, —OS(O)2Re, —OS(O)NRfRg, —OS(O)2NRfRg, —NRfRg, —NReC(O)Rh, —NReC(O)ORh, —NReC(O)NRfRg, —NReC(═NRh)NRfRg, —NReS(O)Rh, —NReS(O)2Rh, —NReS(O)NRfRg, —NReS(O)2NRfRg, —PReRh, —P(ORe)Rh, —P(ORe)(ORh), —P(O)ReRh, —P(O)(ORe)Rh, —P(O)(ORe)(ORh), —SRe, —S(O)Re, —S(O)2Re, or —S(O)2NRfRg; wherein each Re, Rf, Rg, and Rh is independently hydrogen; C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; or Rf and Rg together with the N atom to which they are attached form heterocyclyl. |
