| 发明名称 | Zn<sup>2+</sup>-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors | ||
| 摘要 | Zn2+-chelating motif-tethered fatty acids as histone deacetylase (HDAC) inhibitors. Compounds performed well in in vitro and in vivo tests. | ||
| 申请公布号 | US9115090(B2) | 申请公布日期 | 2015.08.25 |
| 申请号 | US200410597022 | 申请日期 | 2004.12.01 |
| 申请人 | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION | 发明人 | Chen Ching-Shih |
| 分类号 | A61K31/19;C07C233/00;C07D213/81;A61K31/167;A61K31/4402;C07C237/22;C07C237/42;C07C259/06;C07C259/10 | 主分类号 | A61K31/19 |
| 代理机构 | Tarolli, Sundheim, Covell & Tummino LLP | 代理人 | Tarolli, Sundheim, Covell & Tummino LLP |
| 主权项 | 1. A histone deacetylase inhibitor having the formula: wherein: X is chosen from H and CH3; Y is (CH2)n wherein n is 0-2; Z is chosen from (CH2)m wherein m is 0-3 and (CH)2; A is a branched aliphatic group having from 3 to 14 carbons; B is o-aminophenyl or hydroxyl group; and Q is a halogen, hydrogen, or methyl. | ||
| 地址 | Columbus OH US | ||