发明名称 |
Process for the preparation of benzonorbornenes |
摘要 |
The present invention relates to a novel a process for the preparation of 9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-ylamine which process comprises a) reacting cyclopentadiene in the presence of a radical initiator and CXCI3, wherein X is chloro or bromo, to a compound of formula I1, or aa) reacting cyclopentadiene with CXCI3, wherein X is chloro, in the presence of a metal catalyst to a compound of formula I1, wherein X is chloro, b) reacting the compound of formula I1 with a base in the presence of an appropriate solvent to the compound of formula III, c) and converting the compound of formula III in the presence of 1,2-dehydro-6-nitrobenzene to the compound of formula IV, and d) hydrogenating the compound of formula IV in the presence of a metal catalyst.; |
申请公布号 |
US9115043(B2) |
申请公布日期 |
2015.08.25 |
申请号 |
US200913126380 |
申请日期 |
2009.09.28 |
申请人 |
Syngenta Crop Protection, LLC |
发明人 |
Gribkov Denis;Antelmann Bjorn;Giordano Fanny;Walter Harald;De Mesmaeker Alain |
分类号 |
C07C211/45;C07C17/32;C07C17/23;C07C17/26;C07C17/266;C07C22/02;C07C201/12;C07C205/11;C07C209/36;C07C205/12 |
主分类号 |
C07C211/45 |
代理机构 |
|
代理人 |
Jones R. Kody |
主权项 |
1. A process for the preparation of 9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-ylamine of formula I which process comprises a) reacting cyclopentadiene with CXCl3, wherein X is chloro or bromo, in the presence of a radical initiator to a compound of formula II wherein X is chloro or bromo, or aa) reacting cyclopentadiene with CXCl3, wherein X is chloro, in the presence of a metal catalyst to a compound of formula II wherein X is chloro, b) reacting the compound of formula II with a base in the presence of an appropriate solvent to the compound of formula III c) and converting the compound of formula III in the presence of 1,2-dehydro-6-nitrobenzene to the compound of formula IV and d) hydrogenating the compound of formula IV with a hydrogen source in the presence of a metal catalyst. |
地址 |
Greensboro NC US |