主权项 |
1. A method of using a compound, the method comprising:
administering the compound into a body of a patient; exposing the compound that is in the body of the patient to visible or infrared red light, thereby causing spectral energy to emanate from the compound; detecting the spectral energy emanated from the compound in the body; and assessing renal function of the patient based on the detected spectral energy, the compound being of Formula I, wherein: each of X1 and X2 is independently —CN, —CO2R1, —CONR2R3, or —CONH(PS); each of Y1 and Y2 is independently —NR4R5 or Z1 is a single bond, —CR18R19—, —O—, —NR20—, —NCOR21—, —S—, —SO—, or —SO2—; each of R1 to R5 and R18 to R21 is independently —H, —CH2(CHOH)aR44, —CH2(CHOH)aCO2H, —(CHCO2H)aCO2H, —(CH2CH2O)cR49, —(CH2)aSO3H, —(CH2)aSO3−, —(CH2)aNHSO3H, —(CH2)aNHSO3−, —(CH2)aPO3H2, —(CH2)aPO3H−, or —(CH2)aPO3=; each of R44 and R49 is independently —H or —CH3; (PS) is a sulfated or non-sulfated polysaccharide chain comprising one or more monosaccharide units connected by glycosidic linkages; and ‘a’ is an integer from 1 to 10, ‘c’ is an integer from 1 to 100, and each of ‘m’ and ‘n’ independently is an integer from 1 to 3. |