| 主权项 |
1. A device (1) for the manipulation of a liquid sample (2), comprising:
a support (3) which forms a fluidic system (4), a separating device (6) for the sample (2), which is arranged on a first region (3A) of the support (3), a reservoir (4B) disposed in a second region (3B) of the support, a receiving channel (4A) disposed between the first region (3A) and the reservoir (4B), a conveying device (7) configured to generate both negative pressure and positive pressure for conveying the liquid sample (2), where the conveying device (7) is arranged on the second region (3B) of the support (3), separate from the separating device (6), or is integrated therein, at least one vent channel (7E) having a first end in fluid communication with the conveying device (7), extending from the conveying device (7) and adjacent to the receiving channel (4A), and having a second end terminating in region between the first and second regions of the support (3); a separating mechanism (3C) configured to separate the first region (3A) from the second region (3B) and to sever the receiving channel (4A) and the vent channel (7E) therebetween, wherein: prior to the separating mechanism (3C) separating the first region (3A) from the second region (3B), the conveying device (7) is configured to generate negative pressure to at least assist in drawing the liquid sample (2) from the first region (3A) of the support (3), through the receiving channel (4A) and into the reservoir (4B) and the first end of the vent channel (7E) that is in fluid communication with the conveying device (7) does not influence the negative pressure therein as the second end of the vent channel (7E) is terminated and is not in fluid communication with an exterior of the fluidic system (4), after the separating mechanism (3C) separates the first region (3A) from the second region (3B) and severs the vent channel (7E) therebetween, the first end of the vent channel (7E) is configured to prevents any residual influence of the negative pressure in the conveying device, as a result of a severed end of the vent channel (7E) being in fluid communication with an exterior of the fluidic system (4), and after the separating mechanism (3C) separates the first region (3A) from the second region (3B) and severs the receiving channel (4A) therebetween, the conveying device (7) is configured to generate positive pressure to at least assist in forcing the liquid sample (2) from the reservoir (4B) and out of the device (1) through the receiving channel (4A). |
