Method for modulating or controlling sodium channel current by reactive oxygen species (ROS) originating from mitochondria

摘要

Method for modulating or controlling sodium channel current of a cell includes inducing mitochondrial reactive oxygen species (ROS) production in the cell.

主权项

1. A method of reducing arrhythmic risk in an individual with elevated intracellular NADH level, comprising the steps of:
a) providing an individual with elevated intracellular NADH level; b) lowering the intracellular NADH level to a predetermined normal level by administering to the individual a therapeutic amount of a mitochondrial targeted antioxidant; and c) wherein achieving the normal intracellular NADH level reduces arrhythmic risk in the individual.