发明名称 |
METHOD FOR THE TREATMENT OF NEUROLOGICAL DISORDERS BY ENHANCING THE ACTIVITY OF .BETA.-GLUCOCEREBROSIDASE |
摘要 |
<p>Provided is a method of increasing the stability of wild-type .beta.- glucocerebrosidase. Also provided are methods of treating and/or preventing an individual having a neurological disease in which increased expression or activity of .beta.-glucocerebrosidase in the central nervous system would be beneficial. This method comprises administering an effective amount of a pharmacologic chaperone for .beta.- glucocerebrosidase, with the proviso that the individual does not have a mutation in the gene encoding .beta.-glucocerebrosidase. Further provided are .beta.-glucocerebrosidase inhibitors which have been identified as specific pharmacologic chaperones and which have been shown to increase activity of .beta.-glucocerebrosidase in vivo in the central nervous system.</p> |
申请公布号 |
CA2656643(C) |
申请公布日期 |
2015.08.25 |
申请号 |
CA20072656643 |
申请日期 |
2007.06.25 |
申请人 |
AMICUS THERAPEUTICS, INC. |
发明人 |
WUSTMAN, BRANDON |
分类号 |
A61K31/445;A61K31/437;A61K31/7042;A61P25/28 |
主分类号 |
A61K31/445 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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