Sequence scheduling and sample distribution techniques

摘要

A technique is disclosed for sample management for use in conjunction with sequencing devices that sequence biological samples, e.g., DNA and RNA. A sequencing device or a network of sequencing devices may be scheduled according to the characteristics of the samples in queue and the capabilities and availability of sequencing devices. Biological samples may be automatically queued and loaded via a sample distribution system. A sample distribution system may be used to reduce operator intervention.

主权项

1. A sequencing device, comprising:
a sample device configured to receive a biological sample and process the biological sample during a sequencing run; a detection module coupled to the sample device, wherein the detection module comprises detection circuitry configured to acquire sequence data representative of nucleotide identities from the biological sample during the sequencing run; and at least one processor programmed to:
receive the sequence data as the sequencing run is in progress;determine the nucleotide identities of the biological sample based on the sequence data;generate one or more files comprising the nucleotide identities;analyze the nucleotide identities to determine if the acquired sequence data from the biological sample is sufficient; andprovide an indication that the sequencing device is available in response to determining that the sequence data from the biological sample is sufficient to determine a characteristic of the biological sample, wherein the indication is provided while the detection module is acquiring additional sequence data from the biological sample during the sequencing run and before the sequencing run is complete; wherein the processor is programmed to reassign the detection module to sequence a second biological sample after sufficient sequence data from the biological sample has been acquired and before the sequencing run is complete.