发明名称 |
Salt of abexinostat, associated crystalline form, a process for their preparation and pharmaceutical compositions containing them |
摘要 |
Abexinostat tosylate of formula (II):;
and its crystalline form I characterized by its X-Ray powder diffraction diagram, its Raman spectrum and its solid-state 13C CP/MAS NMR spectrum.
;Medicinal products containing the same which are useful in the treatment of cancer. |
申请公布号 |
US9115108(B2) |
申请公布日期 |
2015.08.25 |
申请号 |
US201414195186 |
申请日期 |
2014.03.03 |
申请人 |
PHARMACYCLICS, INC. |
发明人 |
Pimont-Garro Anne;Letellier Philippe |
分类号 |
C07D307/85;C07C309/30 |
主分类号 |
C07D307/85 |
代理机构 |
Hueschen and Sage |
代理人 |
Hueschen and Sage |
主权项 |
1. A crystalline form I of abexinostat tosylate of formula (II):having an X-ray powder diffraction diagram having the following diffraction lines (Bragg's angle 2 theta, expressed in degrees ±0.2°): 6.50, 9.94, 11.35, 12.33, 14.08, 18.95, 21.08, and 27.05. |
地址 |
Sunnyvale CA US |