Therapeutic compositions and related methods of use

摘要

Compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.

主权项

1. A compound of formula (II) or a pharmaceutically acceptable salt thereof, wherein: n is 1 or 2; X is O, S, NRb, or cycloalkylenyl; R1 is selected from optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted cycloalkyl, an optionally substituted aralkyl, and optionally substituted heteroaralkyl; R2 is an optionally substituted quinolinyl; and Rb is hydrogen or alkyl.