Block copolymer having phenylboronic acid group introduced therein, and use thereof

摘要

A block copolymer includes a polyamino acid chain segment and a hydrophilic polymer chain segment. The polyamino acid chain segment includes at least one amino acid residue having a side chain that contains a cationic group and at least one amino acid residue having a side chain that contains a substituted phenylboronic acid group. In the substituted phenylboronic acid group, at least one hydrogen of the phenyl ring is substituted so that the phenylboronic acid group has a pKa of less than 8. Such a block copolymer serves as a carrier that simultaneously imparts stability to a biotechnology-based drug in blood and provides suitable drug-releasing properties of the drug at an affected area.

主权项

1. A pharmaceutical composition, comprising a complex of:
a block copolymer having a polyamino acid chain segment and a hydrophilic polymer chain segment, and a nucleic acid, wherein the polyamino acid chain segment includes at least one amino acid residue having a side chain that contains a cationic group and at least one amino acid residue having a side chain that contains a substituted phenylboronic acid group, at least one hydrogen atom of the phenyl ring of the substituted phenylboronic acid group has been substituted so that the substituted phenylboronic acid group has a pKa of less than 8, and the nucleic acid is reversibly covalently bound to the substituted phenylboronic acid group.