Method of use and preparation of HSA fusion protein composition for skincare

摘要

The present invention provides a recombinant fusion protein which stimulates the rejuvenation and reactivation of skin and epidermal cells for improving skin appearance, smoothing wrinkles and freckles, and whitening skin. Particularly, the present invention provides various types of products for improving skin, which contain recombinant fusion protein of human serum albumin (HSA) with cytokine peptides (EGF, FGF, KGF, HGH, HGF, PDGF, GCSF, interferon, IL-11 or IGF) by genetic engineering technology. The fusion protein can be used independently or in a combination or combination with yeast fermentation products, or with varied emulsifiers, thickeners, moisturizer, preservatives, yeasts and ferments.

主权项

1. A method of skincare comprising topically applying a skincare composition to a subject, said skincare composition comprising a non-glycosylated human serum albumin (HSA)/human epidermal cell growth factor (hEGF) fusion protein expressed in Pichia pastoris, wherein the Pichia pastoris used in expression of the non-glycosylated HSA/hEGF fusion protein is a yeast expression strain in Deposit No. CGMCC 2072 at China General Microbiological Culture Collection (CGMCC) center.