COMPOSITIONS AND METHODS RELATED TO DISEASES ASSOCIATED WITH DEPOSITS OF AMYLOID, TAU, AND ALPHA-SYNUCLEIN

摘要

Disclosed are compositions, comprising one or more immunogens, wherein each immunogen comprises at least two regions, wherein one region comprises at least one amyloid-β (Aβ) B cell epitope or at least one Tau B cell epitope or at least one α-synuclein B cell epitope or combinations thereof, and a second region comprises at least one foreign T helper cell (Th) epitope, and usually multiple foreign Th epitopes. Methods of making and using the compositions are also disclosed.

主权项

1. A composition, comprising at least one immunogen,
wherein each at least one immunogen comprises a region A coupled to a region B; wherein region A comprises (a) at least one Tau B cell epitope, or (b) at least one α-synuclein B cell epitope, or (c) a combination of at least one amyloid-β (Aβ) B cell epitope and at least one Tau B cell epitope, or (d) a combination of at least one amyloid-β (Aβ) B cell epitope and at least one α-synuclein B cell epitopes, or (e) a combination of at least one Tau B cell epitope and at least one α-synuclein B cell epitope, or (f) a combination of at least one amyloid-β (Aβ) B cell epitope and at least one Tau B cell epitope and at least one α-synuclein B cell epitope, and region B comprises a plurality of foreign T helper cell (Th) epitopes.