| 摘要 |
PROBLEM TO BE SOLVED: To provide compounds, compositions and methods for systemic and local delivery of biologically active molecules stable in blood circulation and useful in therapeutic, research, and diagnostic applications that rely upon efficient transfer of the biologically active molecules into cells, tissues, and organs.SOLUTION: The invention relates to symmetrical polyamine derivatives represented by the formula in the figure, and to formulations comprising the compounds. (In the formula, n1 to n3 are each independently integer from 1 to 4; X and X' are each independently a bond, O, or N; R1 and R2 are each independently C8-C25 hydrocarbon groups including 1-4 double or triple bonds; and G is a polymer moiety.) |
