Use of Interleukin-27 as a Diagnostic Biomarker for Bacterial Infection in Critically Ill Patients

摘要

Embodiments of the invention are directed to methods of diagnosing bacterial infection in a critically ill patient. The methods include obtaining a sample from the patient and determining the patient's level of IL-27 expression. Embodiments of the invention are also directed to methods that include determining both the patient's levels of IL-27 expression and PCT expression and using the combined result to provide a diagnosis of bacterial infection in a critically ill patient.

主权项

1. A method for differentiating between sterile inflammation and bacterial infection in critically ill patients with fever and other signs of the systemic inflammatory response syndrome (SIRS) with high specificity and a high positive predictive value, comprising:
obtaining a serum sample from a critically ill patient (meeting criteria for SIRS or sepsis); measuring serum IL-27 protein concentration in said sample; treating said patient for bacterial infection where the serum IL-27 protein concentration is 5 ng/ml or higher.