| 发明名称 |
HIGH-EFFICIENCY, SODIUM -SPECIFIC, BLUE-SHIFTED CHANNELRHODOPSINS |
| 摘要 |
Methods and compositions used to identify and characterize a new channelrhodopsin derived from algae which is highly efficient, sodium specific and blue-shifted. The rhodopsin domain of this channelrhodopsin can be cloned and expressed in mammalian systems and thus used in optogenetic applications and as therapeutic agents. |
| 申请公布号 |
US2015232528(A1) |
申请公布日期 |
2015.08.20 |
| 申请号 |
US201514625307 |
申请日期 |
2015.02.18 |
| 申请人 |
BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
SPUDICH John Lee;Govorunova Elena G.;Sineshchekov Oleg A. |
| 分类号 |
C07K14/705;A61K9/00 |
主分类号 |
C07K14/705 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A recombinant nucleic acid operatively linked to a heterologous promoter sequence, said recombinant nucleic acid comprising:
a) a sequence that encodes a peptide with at least 70% homology to an amino acid sequence selected from SEQ ID NO: 1 or SEQ ID NO: 3; or b) a sequence that encodes a peptide comprising 225 contiguous amino acids selected from SEQ ID NO: 1 or SEQ ID NO: 3; or c) a sequence that hybridizes to the nucleotide sequence of SEQ ID NO:2, or the complement thereof. |
| 地址 |
Austin TX US |
