| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to field of biotechnology, namely to obtaining modified glucagon peptides, and can be used in medicine. Obtained is glucagon peptide with glucagon agonist activity, characterised by amino acid sequence SEQ ID NO: 1, containing up to 7 amino acid substitutions with respect to SEQ ID NO: 1, where one of amino acid substitutions represents substitution of glutamine in position 3 of sequence. SEQ ID NO: 1 for amino acid, containing side chain of structure I, and where amino acid in position 16 of glucagon peptide represents aminoisobutyric acid (AIB).EFFECT: invention makes it possible to obtain glucagon agonists, possessing higher solubility and stability.12 cl, 17 dwg, 12 tbl, 28 ex |
