| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: presented is a group of inventions involving an anticancer agent for combined application of a compound representing N-(2-fluor-4-{[2-({[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide or its pharmaceutically acceptable salt of formula (I), and the compound 4-[3-chlor-4-(cyclopropylamino-carbonyl)amino-phenoxy]-7-methoxy-6-quinolinecarboxamide or its pharmaceutically acceptable salt of formula (II), (versions), an anticancer pharmaceutical composition containing the compound of formula (I) and the compound of formula (II), as well as a method of treating cancer. The compound of formula (I), the compound of formula (II).EFFECT: excellent anticancer effect on various types of cancer as compared to using the declared compounds separately.5 cl, 5 dwg, 5 tbl |
