| 发明名称 |
METHOD FOR EVALUATING THERAPEUTIC EFFECTS OF LAPATINIB ON LIVER CANCER |
| 摘要 |
The invention discloses a method for evaluating therapeutic effects of lapatinib on liver cancer comprising: obtaining a liver cancer biopsy from a patient; determining level of a biomarker in the liver cancer biopsy obtained from the patient ex vivo; comparing the determined level of the biomarker in the liver cancer biopsy obtained from the patient to a reference level of the biomarker; and predicting therapeutic effect of lapatinib on liver cancer according to the comparison between the determined level and the reference level of the biomarker; wherein the reference level of the biomarker is level of the biomarker in a liver biopsy obtained from a normal, non-cancerous subject; wherein the biomarker is HBx or ErbB3. |
| 申请公布号 |
US2015232956(A1) |
申请公布日期 |
2015.08.20 |
| 申请号 |
US201414262266 |
申请日期 |
2014.04.25 |
| 申请人 |
I-SHOU UNIVERSITY |
发明人 |
CHEN YUN-JU;HUANG WEI-CHIEN;CHEN JHEN-YU;CHIEN PEI-HSUAN;CHEN WEN-SHU |
| 分类号 |
C12Q1/70;C12Q1/68 |
主分类号 |
C12Q1/70 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method for evaluating therapeutic effects of lapatinib on liver cancer comprising:
obtaining a liver cancer biopsy from a patient; determining level of a biomarker in the liver cancer biopsy obtained from the patient ex vivo; comparing the determined level of the biomarker in the liver cancer biopsy obtained from the patient to a reference level of the biomarker; and predicting therapeutic effect of lapatinib on liver cancer according to the comparison between the determined level and the reference level of the biomarker; wherein the reference level of the biomarker is level of the biomarker in a liver biopsy obtained from a normal, non-cancerous subject; wherein the biomarker is HBx or ErbB3. |
| 地址 |
Kaohsiung TW |
