| 摘要 |
PROBLEM TO BE SOLVED: To provide: steroid compounds with increased resistance against metabolism and increased water solubility which act on the γ-aminobutyric acid receptor-chloride ionophore (GABA-R) complex and are used in the treatment of disorders of the central nervous system (CNS); and methods for their manufacture.SOLUTION: The present invention provides methods of the manufacture of pharmaceuticals for the treatment of steroid related or steroid induced CNS disorders and methods of prevention, alleviation or treatment of the disorders, by using GABAA receptor modulators, including 3α-ethynyl, 3&bgr;-hydroxyl, androstan-17-one oxime or a pharmaceutically acceptable salt or solvate thereof. |
