FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE

摘要

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts, hydrates and solvates thereof for use in the treatment of cancer:;

主权项

1. A compound of formula (I) or a pharmaceutically acceptable salt, hydrate or solvate thereof:wherein A is selected fromand wherein:X is selected from O, S, CH2, NRN1 wherein RN1 is selected from H, C1-4alkyl, -LA-NRA1RA2, -LA-ORA,
where LA is C1-3 alkylene and each RA is independently selected from H and C1-4alkyl;Y is selected from H, F, and Cl;R1 is selected from H, F, cyclopropyl, and —CH2—ZB,
wherein ZB is selected from:
H, F, Cl, Me, —CH═CH2, heterocyclyl,—ORB1, —NRB1RB2,-LB1-ORB1A, -LB1-NRB1ARB1B, -LB1-RB1C,—O-LB2-ORB2A, —O-LB2-NRB2ARB2B, —O-LB2-RB2C,—NH-LB2-ORB2A, —NH-LB2-NRB2ARB2B and —NH-LB2-RB2C wherein RB1 and RB2 are each independently H or C1-4alkyl,LB1 is C1-3 alkylene, RB2A and RB1B are each independently H or C1-4alkyl and RB1C is heterocyclyl,and LB2 is C1-3 alkylene, RB2A and RB2B are each independently H or C1-4alkyl and RB2C is heterocyclyl;R2 is selected from H, F, and Me; and R3 is selected from H, F and Me.