AURORA KINASE INHIBITORS

摘要

The invention provides a compound of formula I: or a salt thereof, wherein ring A and R1-R4 have any of the values defined in the specification. The compounds have activity as Aurora B kinase inhibitors and are useful for treating conditions associated with Aurora B kinase activity (e.g. cancer).;

主权项

1. A compound of formula I:wherein:
ring A is substituted with one or more groups independently selected from hydroxy, halo, cyano, nitro, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, methylenedioxy, ethylenedioxy, or (C2-C6)alkanoyloxy, wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy is optionally substituted with one or more halo; R1 is H, halo, cyano, nitro, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, methylenedioxy, ethylenedioxy, or (C2-C6)alkanoyloxy, wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy is optionally substituted with one or more halo; or R1 and R2 taken together are methylenedioxy or ethylenedioxy; R2 is H, halo, cyano, nitro, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, methylenedioxy, ethylenedioxy, or (C2-C6)alkanoyloxy, wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy is optionally substituted with one or more halo; or R1 and R2 taken together are methylenedioxy or ethylenedioxy; or R2 and R3 taken together are methylenedioxy or ethylenedioxy; R3 is H, halo, cyano, nitro, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, methylenedioxy, ethylenedioxy, or (C2-C6)alkanoyloxy, wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy is optionally substituted with one or more halo; or R2 and R3 taken together are methylenedioxy or ethylenedioxy; or R3 and R4 taken together are methylenedioxy or ethylenedioxy; and R4 is H, halo, cyano, nitro, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, methylenedioxy, ethylenedioxy, or (C2-C6)alkanoyloxy, wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy is optionally substituted with one or more halo; or R3 and R4 taken together are methylenedioxy or ethylenedioxy; or a salt thereof.