INFLAMMATION IMAGING AND THERAPY

摘要

An imaging agent comprising a conjugate of an oligosaccharide moiety with an imaging moiety. The oligosaccharide is Lewis A or Lewis B or a mimetic thereof, or a pharmaceutically acceptable salt or PEGylated form of Lewis A or Lewis B or its mimetics. Lewis A and Lewis B and its mimetics are also provided for use in the therapeutic treatment of inflammatory diseases, autoimmune diseases and cancer.

主权项

1. An imaging agent comprising a conjugate of an oligosaccharide with an imaging moiety, wherein the oligosaccharide is Lewis A or Lewis B or a mimetic thereof, or a pharmaceutically acceptable salt or PEGylated form of Lewis A or Lewis B or a Lewis A or B mimetic:wherein R represents the point of attachment to the imaging moiety.