| 摘要 |
<p>C XNRPonhnD)C(AARW 2"'>_1 I)OC-9'252 1.' -38 A BST RA CT The present invention relates to an lLA-A*l 101-restricted WTI peptide, specifically, a peptide comprising an amino acid ;equencc consisting of 9 contiguous amino acids from a WT1 protein, wherein the peptide has an ability to bind to an HlLA-A*l 101 molecule, and has an ability to induce a CTL. The present invention also relates to a peptide dimer having an ability to bind to an HlIA-A*I 101 molecule and having an ability to induce a CTL, in which two peptide monomers each comprising an amino acid sequence consisting of 9 contiguous amino acids from a WTI protein and comprising at least one cysteine residue are bound to each other through a disulfide bond. Furthermore, the present invention relates to a polynuclcotide encoding the peptide, a pharmaceutical composition for the treatment and/or prevention of a cancer comprising the same and the like.</p> |
