| 发明名称 |
METHODS AND PRODUCTS FOR TREATING PROLIFERATIVE DISEASES |
| 摘要 |
Methods and products for treating proliferative diseases, and wounds, using as a pharmacon an autophagy inhibitor, a glycolytic inhibitor, and/or an agent able to alter cellular production of reactive oxygen, or combination thereof, optionally in combination with one or more chemotherapeutic agents. In some embodiments, the invention combines a 4-aminoquinoline, exemplified by chloroquine, with a glycolytic inhibitor, exemplified by 2-deoxy-D-glucose and anti-VEGF antibodies. The systems and methods of the invention may be used to treat drug-resistant or multi-drug resistant cancers |
| 申请公布号 |
US2015231237(A1) |
申请公布日期 |
2015.08.20 |
| 申请号 |
US201514704185 |
申请日期 |
2015.05.05 |
| 申请人 |
The Regents of the University of Colorado, a body corporate |
发明人 |
Newell-Rogers Martha Karen;Rogers Susannah K. |
| 分类号 |
A61K39/395;A61K45/06;A61K31/4706 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating melanoma, comprising:
administering to a subject a therapeutically acceptable amount of an autophagy inhibitor and an anti-VEGF antibody in an effective amount to treat the melanoma. |
| 地址 |
Denver CO US |
