| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to compounds of formula I or its pharmaceutically acceptable salts. The compounds according to the invention possess the properties of JAK2 kinase inhibitor. In formulaRrepresents H, C(O)OR, wherein Rmeans H or C-Calkyl, phenyl, optionally substituted by 1-2 groups specified in C-Calkyl which can be substituted in its turn by hydroxy, C-Calkoxy, NRRgroup, wherein Rand Rindependently represent H, C-Calkyl, optionally substituted by C-Calkoxy or morpholino, or together with N atom to which they are attached form piperazinyl substituted by C-Calkyl, or morpholino, or S(O)Rgroup, wherein Rmeans C-Calkyl; OR, wherein Rmeans H, CF, C-Calkyl, optionally substituted by C-Calkoxy, NRR, wherein Rand Rindependently represent H or C-Calkyl, by heterocyclyl specified in morpholinyl and pyrrolidinyl; halogen; CN; CF; S(O)Rgroup, wherein Rmeans C-Calkyl, S(O)NRRgroup, wherein Rand Rindependently represent H, C-Calkyl, NRRgroup, wherein Rand Rindependently represent H or C-Calkyl, or together with N atom to which they are attached form piperazinyl; heterocyclyl specified in tetrahydropyranyl, piperazinyl optionally substituted by C-Calkyl or C-CalkoxyC-Calkyl, morpholinyl and pyrrolidinyl; C(O)NRRgroup, wherein Rand Rindependently represent H, C-Calkyl, C-Ccycloalkyl optionally substituted by hydroxy, or piperidinyl optionally substituted by C-Calkyl, or together with N atom to which they are attached form piperazinyl substituted by acetyl, morpholino or piperidinyl substituted by hydroxy; the other values of R, as well as of the other radicals are presented in the patent claim. The invention also refers to the specific compounds the structural formulas of which are presented in the patent claim.EFFECT: new compounds which possess the properties of JAK2 kinase inhibitor are produced.19 cl, 2 tbl, 438 ex |
