CONJUGATES FOR PREVENTION OR TREATMENT OF NICOTINE ADDICTION

摘要

PROBLEM TO BE SOLVED: To provide nicotine-derived haptens, nicotine-derived hapten-carrier conjugates, and vaccine compositions containing the conjugates, which are useful for enhancing smoking quit rates or reducing smoking relapse rates in smoking cessation therapy and for prevention or treatment of nicotine addiction.SOLUTION: The present invention relates to nicotine-derived hapten-carrier conjugates represented by the formula (III). [W is -CH- or -O-; -(spacer)- is a C-Calkylene group, a C-Calkylene group interrupted by 1 to 4 oxygen atoms and optionally interrupted by a -N(H)C(O)-, or the like; Xis -NH- or the like; m is 0 or 1; n is an integer from 1 to 1000; and Y is a carrier protein such as bacterial toxoids.]