发明名称 |
ACETAMINOPHEN PROTEIN ADDUCTS AND METHODS OF USE THEREOF |
摘要 |
The present disclosure relates to acetaminophen protein adducts and methods of diagnosing acetaminophen toxicity using the acetaminophen protein adducts. The present disclosure provides acetaminophen (APAP)-protein adducts and methods of detecting acetaminophen-induced toxicity in a subject using APAP-protein adducts. One aspect of the present disclosure provides an APAP- prptein adduct for diagnosing acetaminophen-induced toxicity. According to the present disclosure, the inventors have identified proteins that are modified by N-acetyl-pbenzoquinoneimine (NAPQI) in subjects with acetaminophen-induced toxicity. Non-limiting examples of proteins modified by NAPQI include betaine-homocysteine S-methyltransferase 1, cytoplasmic aspartate aminotransferase, 1,4-alpha-glucan branching enzyme, formimidoyltransferase-cyclodeaminase, and dystrophin. |
申请公布号 |
CA2936907(A1) |
申请公布日期 |
2015.08.20 |
申请号 |
CA20152936907 |
申请日期 |
2015.02.13 |
申请人 |
ARKANSAS CHILDREN'S HOSPITAL RESEARCH INSTITUTE, INC.;THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS |
发明人 |
JAMES, LAURA P.;HINSON, JACK;ROBERTS, DEAN;GILL, PRITMOHINDER S. |
分类号 |
A61K31/167 |
主分类号 |
A61K31/167 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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