发明名称 |
Site-specific insulin conjugate |
摘要 |
The present invention relates to: an insulin conjugate, wherein a non-peptidic polymer and an immunoglobulin Fc region are site-selectively connected, by a covalent bond, to an amino acid residue of a region excluding the N terminal of insulin &bgr; chain, and thus the binding force to an insulin receptor is improved, thereby increasing activity; an extended release preparation containing the same; and a method for preparing the same. The insulin conjugate of the present invention can provide an insulin preparation with remarkably improved |
申请公布号 |
AU2014221534(A1) |
申请公布日期 |
2015.08.20 |
申请号 |
AU20140221534 |
申请日期 |
2014.02.26 |
申请人 |
HANMI PHARM. CO., LTD. |
发明人 |
JANG, MYUNG HYUN;KIM, DAE JIN;HWANG, SANG YOUN;KIM, HYUN UK;JUNG, SUNG YOUB;KWON, SE CHANG |
分类号 |
C07K14/62;A61K38/28;A61P3/10;C07K17/08 |
主分类号 |
C07K14/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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