SALTS OF PRODRUGS OF PIPERAZINE AND SUBSTITUTED PIPERIDINE ANTIVIRAL AGENTS

摘要

This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection.;;wherein:

X is C or N with the proviso that when X is N, R1 does not exist;

W is C or N with the proviso that when W is N, R2 does not exist;

V is C;

E is hydrogen or a pharmaceutically acceptable salt thereof; and

Y is selected from the group consisting of
;;Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I.;;wherein:

L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.

主权项

1. A pharmaceutically acceptable salt of the compound 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine, having the following structure: