发明名称 METHOD OF REDUCING A FERMENTATION AND/OR ENZYME INHIBITOR IN A SACCHARIDE-CONTAINING COMPOSITION
摘要 Provided is a method of treating a saccharide-containing composition, the method comprising contacting a composition containing a saccharide with a compound of formula (I) or a salt thereof;;wherein R1-R4, X, and n are as described herein. Further provided is a composition comprising a saccharide and a compound of formula (I) or a salt thereof.
申请公布号 US2015232958(A1) 申请公布日期 2015.08.20
申请号 US201414182565 申请日期 2014.02.18
申请人 Renmatix, Inc. 发明人 Lipiecki Francis;Arora Sachin
分类号 C13K1/04;C13K13/00;C12P7/06 主分类号 C13K1/04
代理机构 代理人
主权项 1. A method of treating a saccharide-containing composition comprising contacting a composition containing a saccharide with a compound of formula (I) or a salt thereofwherein (1) R1-R4 are the same or different and each is independently selected from —H, -M, C1-C8 alkyl, C2-C8 alkenyl, C3-C6 cycloalkyl, aryl, heteroaryl, alkylene oxide, oligoalkylene oxide, polyalkylene oxide, —R7OR8, —R7OM, —CONH2, —R7CONH2, —CONHOH, —R7CONHOH, —C(O)OR7, —R8C(O)OR7, —C(O)OM, —R7C(O)OM, —C(O)R7, —R8C(O)R7, —C(O)N(R7)R8, —R9C(O)N(R7)R8, —C(O)NR7SO2N(R8)R9, —R10C(O)NR7SO2N(R8)R9, —R7PO4, —R7PO(OH)2, —R7PO(OH)(OR8), —R7PO(OR8)2, —R7SO3H, —R7SO2NR8OH, —R7SR8, —R7SOR8, —R7SO2R8, —R7SO2NR8(R9), —R7SO2NR8CON(R9)R10, —R7NO2, —R7NR8R9, —R7NR8C(O)R9, —R7N(R8)C(O)R9, —R7NR8SO2R9, —R7N(R8)SO2R9, —R7NR8R9R10M, K7K8M, and any of the foregoing groups other than —H that is optionally substituted; or any two of R1-R4 taken together is a divalent counterion, and the other two of R1-R4 is defined as in (1); or any three of R1-R4 taken together is a trivalent counterion, and the other one of R1-R4 is defined as in (1); or any two of R1-R4 taken together is a divalent counterion, and the other two of R1-R4 is the same or a different divalent counterion; or all of R1-R4 taken together is a tetravalent counterion; (2) each X is the same or different and each is independently selected from —H, —OH, C1-C8 alkyl, C2-C8 alkenyl, C3-C6 cycloalkyl, aryl, heteroaryl, alkylene oxide, oligoalkylene oxide, polyalkylene oxide, heterocycloalkyl, C1-C8 haloalkyl, halo, —CN, —R7CN, —NO2, —R7NO2, —OR7, —R7OR8, —OR7OR8, —OM, —R7OM, —CONH2, —R7CONH2, —CONHOH, —R7CONHOH, —C(O)OR7, —R8C(O)OR7, —C(O)OM, —R7C(O)OM, —C(O)R7, —R8C(O)R7, —C(O)N(R7)R8, —R9C(O)N(R7)R8, —C(O)NR7SO2N(R8)R9, —R10C(O)NR7SO2N(R8)R9, —PO4, —R7PO4, —PO(OH)2, —R7PO(OH)2, —PO(OH)(OR7), —R8PO(OH)(OR7), —PO(OR7)2, —R8PO(OR7)2, —SO3H, —SO3M, —R7SO3H, —R7SO3M, —R7SO3R8, —SO2NR7OH, —R8SO2NR7OH, —SR7, —R8SR7, —SOR7, —R8SOR7, —SO2R7, —R8SO2R7, —SO2NR7(R8), —R9SO2NR7(R8), —SO2NR7CON(R8)R9, —R10SO2NR7CON(R8)R9, —NR7R8, —R9NR7R8, —NR7C(O)R8, —R9NR7C(O)R8, —N(R7)C(O)R8, —R9N(R7)C(O)R8, —NR7SO2R8, —R9NR7SO2R8, —N(R7)SO2R8, —R9N(R7)SO2R8, —NR7R8R9M, —R10NR7R8R9M, and any of the foregoing groups other than —H that is optionally substituted; or two X substituents can be taken together with the carbon atoms to which they are attached to form a 5- or 6-membered aryl, cycloalkyl or heterocycloalkyl comprising 1 or 2 heteroatoms selected from the group consisting of N, O, and S; and (3) R7, R8, R9, and R10 are the same or different and each is independently selected from —H, C1-C8 alkyl, C3-C6 cycloalkyl, aryl, heteroaryl, alkylene oxide, oligoalkylene oxide, polyalkylene oxide, and any of the foregoing groups other than —H that is optionally substituted; and (4) M is a monovalent counterion; and (5) n is 0 or an integer of 1 to 4.
地址 King of Prussia PA US