| 发明名称 |
METHOD FOR PROGNOSIS OF GLOBAL SURVIVAL AND SURVIVAL WITHOUT RELAPSE IN HEPATOCELLULAR CARCINOMA |
| 摘要 |
The present invention relates to the technical field of hepatocellular carcinoma (HCC) management, and more precisely to the prognosis of HCC aggressiveness and associated therapeutic decisions. The invention provides a new prognosis method of HCC aggressiveness, based on determination in vitro and analysis of an expression profile comprising genes TAF9, RAMP3, HN1, KRT19, and RAN. The invention also provides kits for the prognosis of HCC aggressiveness, and methods of treatment of HCC in a subject based on a preliminary prognosis of said subject HCC aggressiveness. |
| 申请公布号 |
US2015232944(A1) |
申请公布日期 |
2015.08.20 |
| 申请号 |
US201314429515 |
申请日期 |
2013.09.23 |
| 申请人 |
INTEGRAGEN ;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ;UNIVERSITE PARIS DESCARTES |
发明人 |
De Reynies Aurelien;Laurent-Puig Pierre;Zucman-Rossi Jessica;Nault Jean-Charles |
| 分类号 |
C12Q1/68;G06F19/20;G06F19/00 |
主分类号 |
C12Q1/68 |
| 代理机构 |
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代理人 |
|
| 主权项 |
1. A method of in vitro prognosis of global survival and/or survival without relapse in a subject suffering from HCC from a liver sample of said subject, comprising:
a) Determining in vitro from said liver sample an expression profile comprising the 5 following genes: TAF9, RAMP3, HN1, KRT19, and RAN; and b) Prognosing global survival and/or survival without relapse based on said expression profile, using an algorithm calibrated with at least one reference HCC liver sample. |
| 地址 |
Evry FR |
