发明名称 |
FRIZZLED-BINDING AGENTS AND USES THEREOF |
摘要 |
Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided. |
申请公布号 |
US2015232554(A1) |
申请公布日期 |
2015.08.20 |
申请号 |
US201514605560 |
申请日期 |
2015.01.26 |
申请人 |
OncoMed Pharmaceuticals, Inc. |
发明人 |
GURNEY Austin L.;Sato Aaron Ken;Axelrod Fumiko Takada;Hoey Timothy Charles;Satyal Sanjeev H.;Mitra Satyajit Sujit Kumar |
分类号 |
C07K16/28;A61K45/06;A61K39/395 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Redwood City CA US |