BIOMARKERS FOR TUBERCULOSIS INFECTION

摘要

Provided herein are compositions, kits, devices, and methods for the detection and/or diagnosis of tuberculosis (TB) infection. In particular, detection and/or quantification of notch ligand delta-like 1 (dll1) expression, notch ligand delta-like 4 (dll4) expression, or a ration thereof in a subject is used as a biomarker for diagnosis of mycobacterial infection.

主权项

1. A method for diagnosing tuberculosis (TB) infection in a subject, comprising:
(a) detecting, in a sample obtained from the subject, the levels of expression products for notch ligand delta-like 1 (dll1) and notch ligand delta-like 4 (dll4); and b) diagnosing said subject as having a latent TB infection or an active TB infection based on the levels of the expression products.