PRODUCTION ANTIBIOTIC 924 A 1

摘要

The microorganism Streptomyces cattleya, preferably the strain NRRL 8057, is cultivated under submerged aerobic conditions in an aqueous nutrient medium containing assimilable C and N sources as well as inorganic salts. N-Acetylthienamycin is obtained. Non-toxic, pharmaceutically acceptable salts of N-acetylthienamycin can be obtained by reaction with inorganic or organic bases. N-acetylthienamycin and its salts show remarkable antibiotic properties and are active against a wide range of pathogens as well as against resistant strains of particular microorganisms. The antibiotic is active against Gram-positive and -negative bacteria and is suitable for use in human and veterinary medicine and as antibacterial agent for commercial and industrial purposes.