发明名称 |
CHIMERIC ANTIGEN RECEPTORS AND METHODS OF MAKING |
摘要 |
Provided are methods of generating chimeric antigen receptors (CAR). In some embodiments, library screening of CAR is performed by generating a vector encoding the CAR from random attachment of vectors from libraries of vectors encoding antigen-binding domains (e.g., scFv regions), hinge regions, and endodomains. In some embodiments, the vectors contain a transposon. |
申请公布号 |
CA2938887(A1) |
申请公布日期 |
2015.08.20 |
申请号 |
CA20152938887 |
申请日期 |
2015.02.16 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
COOPER, LAURENCE, J. N.;KORNGOLD, ANA BEATRIZ;RABINOVICH, BRIAN A.;SINGH, HARJEET;OLIVARES, SIMON |
分类号 |
C12N15/85;C07K14/705;C07K19/00 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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