发明名称 |
Ingenol-3-acylates III and ingenol-3-carbamates |
摘要 |
<p>The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8; or R is X wherein X is -NR11R12; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use -alone or in combination with one or more other pharmaceutically active compounds- in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.</p> |
申请公布号 |
AU2011348637(B2) |
申请公布日期 |
2015.08.20 |
申请号 |
AU20110348637 |
申请日期 |
2011.12.22 |
申请人 |
LEO LABORATORIES LIMITED |
发明人 |
GRUE-SORENSEN, GUNNAR;LIANG, XIFU;HOGBERG, THOMAS;MANSSON, KRISTOFFER;VEDSO, PER;VIFIAN, THOMAS |
分类号 |
C07C271/34;A61K31/215;A61K31/27;A61K31/381;A61K31/4192;A61K31/42;A61K31/426;A61P35/00;C07C249/06;C07D261/18;C07D277/32;C07D295/21;C07D309/08;C07D333/38;C07D401/04 |
主分类号 |
C07C271/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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