OUTER MEMBRANE VESICLES

摘要

The present invention provides an outer membrane vesicle (OMV) from a Gram-negative bacterium, comprising at least one heterologous protein that is free in the lumen of the OMV, wherein the OMV is capable of eliciting an immune response to the heterologous protein when administered to a mammal. The invention also provides methods for preparing the OMVs of the invention, pharmaceutical compositions comprising the OMVs of the invention, especially immunogenic compositions and vaccines, and methods of generating an antibody immune response in a mammal using OMVs.

主权项

1. A composition comprising an outer membrane vesicle (OMV) from a Gram-negative bacterium and a heterologous protein in the lumen thereof,
wherein the heterolobous protein is not integrally associated with the membrane of the OMV; and wherein the composition is capable of eliciting an immune response to the heterologous protein when administered to a mammal.