发明名称 |
Multimodal silica-based nanoparticles |
摘要 |
The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters, has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound, exhibits high biostability and biocompatibility, may be coated with an organic polymer, such as poly( ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo. The nanoparticle may further be conjugated to a ligand. A therapeutic agent may be attached to the nanoparticle. Further, magnetic resonance imaging (MRI), radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle. |
申请公布号 |
AU2014232907(A1) |
申请公布日期 |
2015.08.20 |
申请号 |
AU20140232907 |
申请日期 |
2014.03.17 |
申请人 |
CORNELL UNIVERSITY;SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
BRADBURY, MICHELLE;WIESNER, ULRICH;PENATE MEDINA, OULA;BURNS, ANDREW;LEWIS, JASON;LARSON, STEVEN;QUINN, TOM |
分类号 |
A61K51/00;A61B5/00;A61K9/50;G01N33/574 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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