发明名称 ANTIBODY-DRUG CONJUGATE
摘要 As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L 1 -L 2 -L P -NH-(CH 2 )n 1 -L a -L b -L c -wherein the antibody is connected to the terminal of L 1 , and the antitumor compound is connected to the terminal of L c with the nitrogen atom of the amino group at position 1 as a connecting position.
申请公布号 EP2907824(A1) 申请公布日期 2015.08.19
申请号 EP20130845596 申请日期 2013.10.10
申请人 DAIICHI SANKYO COMPANY, LIMITED 发明人 MASUDA, TAKESHI;NAITO, HIROYUKI;NAKADA, TAKASHI;YOSHIDA, MASAO;ASHIDA, SHINJI;MIYAZAKI, HIDEKI;KASUYA, YUJI;MORITA, KOJI;ABE, YUKI;OGITANI, YUSUKE
分类号 C07K16/28;A61K31/4745;A61K31/48;A61K39/395;A61K47/48;A61P35/00 主分类号 C07K16/28
代理机构 代理人
主权项
地址