发明名称 Process for manufacturing pyrimidine sulfamide derivatives
摘要 The invention relates to a process for manufacturing the compound of formula I wherein R is H, (C 1 -C 6 )alkyl or benzyl, or a salt thereof, said process comprising the reaction of the compound of formula I-1 wherein X is bromine, chlorine or fluorine, with the compound of formula I-2 wherein R is H, (C 1 -C 6 )alkyl or benzyl, or a salt of said compound of formula I-2, in the presence of tetra-n-butyl ammonium fluoride hydrate and of a base. The invention further relates to the compound of formula I-1 and uses thereof.
申请公布号 EP2907811(A1) 申请公布日期 2015.08.19
申请号 EP20140155137 申请日期 2014.02.14
申请人 ACTELION PHARMACEUTICALS LTD. 发明人 ABELE, STEFAN;FUNEL, JACQUES-ALEXIS;SCHINDELHOLZ, IVAN
分类号 C07D401/12 主分类号 C07D401/12
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