发明名称 |
MCT protein inhibitor-related prognostic and therapeutic methods |
摘要 |
<p>This invention provides a method of identifying one or more subgroups of cancer patients that are likely to benefit from treatment with a monocarboxylate transporter (MCT) protein inhibitor comprising: (a) obtaining a sample of a cancer/tumor tissue from each of said cancer patients; (b) determining the expression level of stromal MCT4 protein in each of said samples of cancer/tumor tissue to obtain a first dataset; and (c) using the expression level of the stromal MCT4 protein from said first dataset to classify each of said sets of one or more cancer patients as stromal MCT4-positive or stromal MCT4-negative, wherein the cancer patients classified as stromal MCT4- positive are patients that are more likely to benefit from treatment with said MCT protein inhibitor. This invention also provides related methods for treating a cancer/tumor whose stromal component expresses the MCT4 protein in a patient.</p> |
申请公布号 |
GB2523211(A) |
申请公布日期 |
2015.08.19 |
申请号 |
GB20140013180 |
申请日期 |
2013.01.25 |
申请人 |
THOMAS JEFFERSON UNIVERSITY |
发明人 |
MICHAEL P LISANTI;FEDERICA SOTGIA |
分类号 |
G01N33/574;A61K31/519;A61K31/522;A61P35/00 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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