MEANS AND METHODS FOR COUNTERACTING, PREVENTING AND/OR DETERMINING HEART FAILURE, OR A RISK OF HEART FAILURE

摘要

The present invention relates to a method for diagnosing and/or prognosing heart failure in a subject the method comprising the step of determining the level of at least one genetic marker in a body fluid sample obtained from said subject, wherein said at least one genetic marker is an miRNA. The invention further relates to a method for treating or preventing heart failure in a subject the method comprising the step of decreasing within said subject the expression, amount, and/or activity of at least one miRNA, or decreasing within said subject the interaction of at least one miRNA with its mRNA target or increasing within said subject the expression, amount, and/or activity of the mRNA target of at least one miRNA.